{"id":865,"date":"2024-02-14T15:38:53","date_gmt":"2024-02-14T13:38:53","guid":{"rendered":"http:\/\/www.amyloid.bti.vu.lt\/?page_id=865"},"modified":"2026-11-13T23:40:16","modified_gmt":"2026-11-13T21:40:16","slug":"mokslas","status":"publish","type":"page","link":"http:\/\/www.amyloid.bti.vu.lt\/lt\/mokslas\/","title":{"rendered":"Research"},"content":{"rendered":"<h2 class=\"wp-block-heading has-palette-color-6-background-color has-background\">Tyrim\u0173 objektai<\/h2>\n\n\n\n<p class=\"has-text-align-left\">M\u016bs\u0173 laboratorijoje tyriami baltymai, kurie sudaro amiloidines fibriles arba la\u0161elius. <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Amiloidin\u0117s fibril\u0117s<\/strong> yra baltym\u0173 agregatai turintys ypatingai tvarking\u0105 beta-klos\u010di\u0173 strukt\u016br\u0105, kurie randami \u012fvairi\u0173 neurodegeneracini\u0173 ir kai kuries atvejais \u0161irides lig\u0173 metu.<\/li>\n\n\n\n<li><strong>Baltyminiai la\u0161eliai <\/strong>susidaro skys\u010di\u0173 fazi\u0173 atskyrimo metu &#8211; fenomenas, kuris atsitinka l\u0105stel\u0117s viduje ir gali inicijuoti baltym\u0173 agregacij\u0105 arba siejamas su tam tikr\u0173 baltym\u0173 funkcijomis.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"395\" src=\"http:\/\/www.amyloid.bti.vu.lt\/wp-content\/uploads\/2020\/05\/schema-1-1024x395.png\" alt=\"Schema iliustruojanti amiloidini\u0173 baltym\u0173 agregacijos proces\u0105.\" class=\"wp-image-191\" srcset=\"http:\/\/www.amyloid.bti.vu.lt\/wp-content\/uploads\/2020\/05\/schema-1-1024x395.png 1024w, http:\/\/www.amyloid.bti.vu.lt\/wp-content\/uploads\/2020\/05\/schema-1-300x116.png 300w, http:\/\/www.amyloid.bti.vu.lt\/wp-content\/uploads\/2020\/05\/schema-1-768x296.png 768w, http:\/\/www.amyloid.bti.vu.lt\/wp-content\/uploads\/2020\/05\/schema-1-1536x592.png 1536w, http:\/\/www.amyloid.bti.vu.lt\/wp-content\/uploads\/2020\/05\/schema-1.png 1766w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Schema iliustruojanti amiloidini\u0173 baltym\u0173 agregacijos proces\u0105.<\/figcaption><\/figure>\n\n\n\n<p>M\u016bs\u0173 laboratorijoje turime patirties su \u0161iais baltymais: <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Alzheimerio liga<\/strong>: Amiloido-beta peptidas, S100 baltym\u0173 \u0161eima, <em>Tau<\/em> baltymas. <\/li>\n\n\n\n<li><strong>Parkinsono liga<\/strong>: Alfa-sinukleinas. <\/li>\n\n\n\n<li><strong>Kempinlig\u0117:<\/strong> Prioniniai baltymai.<\/li>\n\n\n\n<li><strong>Amiotrofin\u0117 lateralin\u0117 skleroz\u0117<\/strong>: \u017dmogaus superoksido dismutaz\u0117 SOD1.<strong> <\/strong><\/li>\n\n\n\n<li><strong>Kitos amiloidoz\u0117s<\/strong>: \u00df2-mikroglobulinas, transtiretinas<\/li>\n\n\n\n<li><strong>Modeliniai baltymai:<\/strong> Insulinas, vi\u0161tos kiau\u0161inio lizocimas. <\/li>\n\n\n\n<li><strong>Bakterij\u0173 ir mieli\u0173 baltyma<\/strong>i: CsgABC, Sup35, Ure2. <\/li>\n\n\n\n<li><strong>Baltyminiai \u0161aperonai ir reguliaciniai baltymai<\/strong>: 14-3-3, Hsp, DegP. <\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading has-palette-color-6-background-color has-background\">Metodika<\/h2>\n\n\n\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<ul class=\"wp-block-list\">\n<li>Gen\u0173 in\u017einerija;<\/li>\n\n\n\n<li>Baltym\u0173 ir nukleor\u016bg\u0161\u010di\u0173 elektroforez\u0117;<\/li>\n\n\n\n<li>Rekombinantini\u0173 baltym\u0173 sintez\u0117s bakterijose metodai;<\/li>\n\n\n\n<li>\u012evair\u016bs chromatografiniai metodai (pvz.: jon\u0173 main\u0173 chromatografija, giminingumo chromatografija, gelfiltracija,  auk\u0161to&nbsp;efektyvumo skys\u010di\u0173&nbsp;chromatografija&nbsp;(HPLC)) skirti gryninti baltymus ir kitas molekules;<\/li>\n\n\n\n<li>Amiloidini\u0173 baltym\u0173 agregacijos proceso sekimas matuojant tirpalo absorbcij\u0105, dinamin\u0119 \u0161viesos sklaid\u0105 ar amiloidams specifini\u0173 da\u017e\u0173 fluorescencijos emisijos intensyvum\u0105,   bei kinetikos duomen\u0173 analiz\u0117 panaudojant chemin\u0117s kinetikos \u012frankius;<\/li>\n\n\n\n<li>Antrin\u0117s amiloidini\u0173 baltym\u0173 bei j\u0173 agregat\u0173 strukt\u016bros nustatymas infraraudon\u0173j\u0173 spinduli\u0173 spektroskopijos metodu;<\/li>\n\n\n\n<li>Amiloidini\u0173 agregat\u0173 morfologijos ir fizini\u0173 parametr\u0173 (ilgio, auk\u0161\u010dio, plo\u010dio, periodi\u0161kumo) nustatymas atomin\u0117s j\u0117gos mikroskopu; <\/li>\n\n\n\n<li>Baltym\u0173 molekulin\u0117s mas\u0117s nustatymas masi\u0173 spektrometru; <\/li>\n\n\n\n<li>Baltym\u0173 strukt\u016bros nustatymai su Cryo-EM <\/li>\n<\/ul>\n<\/div>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Tyrim\u0173 objektai M\u016bs\u0173 laboratorijoje tyriami baltymai, kurie sudaro amiloidines fibriles arba la\u0161elius. M\u016bs\u0173 laboratorijoje turime patirties su \u0161iais baltymais: Metodika<\/p>","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-865","page","type-page","status-publish","hentry"],"rise-blocks_excerpt":"Tyrim\u0173 objektai M\u016bs\u0173 laboratorijoje tyriami baltymai, kurie sudaro amiloidines fibriles arba la\u0161elius. M\u016bs\u0173 laboratorijoje turime patirties su \u0161iais baltymais: Metodika","yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research - Amiloid\u0173 tyrimo sektorius<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.amyloid.bti.vu.lt\/lt\/mokslas\/\" \/>\n<meta property=\"og:locale\" content=\"lt_LT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - Amiloid\u0173 tyrimo sektorius\" \/>\n<meta property=\"og:description\" content=\"Tyrim\u0173 objektai M\u016bs\u0173 laboratorijoje tyriami baltymai, kurie sudaro amiloidines fibriles arba la\u0161elius. 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